BQNAT = Bedaquiline-based treatment following a Negative CBNAAT test

CBNAAT = Cartridge-Based Nucleic Acid Amplification Test (like GeneXpert)

BQNAT regimen is used for drug-resistant TB cases when:

Rifampicin resistance is detected

Patient is eligible for Bedaquiline-containing regimen

Confirmed MDR-TB or XDR-TB, often through Line Probe Assay (LPA) and CBNAAT

BQNAT Regimen – Overview (India’s NTEP Guidelines)

Core Drugs (may vary slightly):

Bedaquiline (BDQ)

Levofloxacin (Lfx) or Moxifloxacin (Mfx)

Linezolid (Lzd)

Clofazimine (Cfz)

Cycloserine (Cs)

Duration: 18–20 months, depending on patient response and tolerability

Regular monitoring: ECG, liver function, electrolytes, adherence

Used In:

Patients with rifampicin-resistant TB (RR-TB) or MDR-TB

If CBNAAT detects Rif resistance, and DST (Drug Susceptibility Testing) guides further drug inclusion

Implemented under National TB Elimination Program (NTEP), India

If you're referring to something else by BQNAT (e.g., a lab test, a program, or a specific guideline), feel free to clarify!

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